Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS: SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

Abstract

FORMULATION AND CHARACTERIZATION OF CLOZAPINE ORO-DISPERSIBLE TABLETS

Dr. M. Sunitha Reddy*, Jakka Sravanthy and S. Muhammad Fazal-Ul-Huq

ABSTRACT

Clozapine (CLOZ) is an atypical antipsychotic agent used in the management of schizophrenia. It exhibits extensive first pass metabolism with poor oral bioavailability (27%–50%) limiting its therapeutic efficiency. The aim of this study is to formulate Oro-Dispersible Tablets with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, mannitol used as diluent in the formulation of tablets by direct compression method. Attempts were made to enhance dissolution rate along with faster disintegration using different excipients like Lactose Anhydrous NF DT, Lactose Monohydrate DCC II SD and Crospovidone. Physical parameters like bulk density, tapped density, carrs index, hausners ratio, angle of repose, weight variation, friability, hardness, content of active ingredient, disintegration time were also studied. Solid state characterisation of samples was carried out by X-ray diffraction (XRD), differential scanning calorimetric (DSC), Fourier transform infrared spectrophotometry (FTIR) studies. In-vitro dissolution studies were carried out with 900ml of 0.1N HCl as dissolution Media. Among the all formulations Crospovidone with 8% shown the lesser disintegration time i.e. 20 mins and higher dissolution rate i.e. 99.99%.

Keywords: Oro-Dispersible Tablets, Clozapine, Lactose Anhydrous NF DT, Lactose Monohydrate DCC II SD, Crospovidone, direct compression method, XRD, DSC, FTIR studies. In-vitro dissolution.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More