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Abstract

ACUTE TOXICITY STUDIES OF POLYHERBAL FORMULATION OF MORINGA OLEIFERA, VIOLA ODORATA, ALLIUM SATIVUM

Meenakshi P. Singh and Jagadeesh Singh SD*

ABSTRACT

The study was aimed at evaluating acute oral toxicity of polyherbal formulation with different combinations of Moringa oleifera, Viola odorata and Allium sativum plant extracts. The toxicity study as carried out using Wistar albino rats. The acute toxicity studies were carried out as per the OECD guidelines 420 where the limit test dose of 2000 mg/kg was utilized. Before dosing the formulation of test item is prepared. The animals were fasted overnight prior to dosing (about 16- 18 hours). Water was provided during fasting period. The test item was given through oral gavages route to each rat as a single dose. Prior to dosing the weight of individual rat was recorded and on that basis the dosage volume was adjusted. The test item was given in a single dose of 2000 mg/kg body weight. All the animals were observed for clinical signs and mortality at 30 min, 1 hr, 2 hr, 3 hr and 4 hr on the first day following dosing and afterwards, one time a day for clinical signs and two times a day for mortality during the fifteen days of test period. The acute toxicity study of polyherbal formulation with different combinations of Moringa oleifera, Viola odorata and Allium sativum plant extracts on Wistar female rats exhibited more than 2000mg/kg with no behavioral changes. There were no clinical signs of toxicity and mortalities observed in the tested doses. Polyherbal formulation up to the dose level 2000mg/kg body weight did not produce any toxic effects or deaths. The acute oral administration of polyherbal formulation was safe and not toxic in a single dose.

Keywords: Toxicity, wistar albino rats, OECD 420, polyherbal formulation.


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