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Abstract

MICROWAVE ASSISTED SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2-(4- ARYLTHIAZOLE-2-YL-AMINO)-N-ARYL ACETAMIDE DERIVATIVES.

Sukeshini B. Lote*, Monali B. Wawre and Babita A. Dodke

ABSTRACT

2-(4- arylthiazole-2-yl-amino)-n-aryl acetamide derivatives were synthesized by microwave heating and evaluated for antimicrobial activity. Acetophenone and thiourea were refluxed with iodine as a catalyst to prepare 2-amino-4aryl thiazole (I). To this anhydrous potassium carbonate and chloroacetylchloride was added to form 4- aryl thiazole-N-substituted-α-chloroacetanilide (II). Newly synthesized compounds (IIIa-d) were obtained by treating various substituted anilines with 4-aryl thiazole-N-substituted-α-chloroacetanilide. These are then confirmed by spectroscopical analysis using uv-visible, IR, H1NMR and mass spectroscopy. All compounds were evaluated for antimicrobial activity against S. Aureaus and A. niger, using Ciprofloxacin and Fluconazole as standard for antibacterial and antifungal activity respectively.

Keywords: 2-(4- arylthiazole-2-yl-amino)-n-aryl acetamide, anilne, antibacterial, antifungal.


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