Abstract

FORMULATION AND DEVELOPMENT OF FAST DISSOLVING TABLETS OF SELECTIVE ANTI HYPERTENSIVE DRUG

*Harekrishna Roy and Bhabani Shankar Nayak

ABSTRACT

The demand for fast disintegrating tablets has been growing, during the last decade especially for geriatric and paediatric patients because of swallowing difficulties. Urapidil is used to treat hypertension. Hence in present work an attempt has been made to formulate Fast dissolving tablet of Urapidil by direct compression technique using various concentration of Superdisintegrants like Crosscarmellose sodium (CCS), Cross povidone (CP) and Sodium starch glycolate (SSG). The formulated tablets were evaluated for Crushing strength, Friability, Thickness, Diameter, Weight variation, Drug content, Wetting time, Water absorption ratio, Disintegration time and Percentage of drug release. All formulations showed satisfactory result. Among them formulation F3 containing 3% of CCS exhibited complete release within 15 minute and disintegration time within 10 second. Accelerated stability study indicated no significant difference in assay and crushing strength. There was no chemical interaction between the drug and excipients during FT-IR study and DSC Study; considered in the present investigation.

Keywords: Fast disintegrating Tablet, Urapidil, Direct compression technique, Inteaction.