Abstract

DERMAL DELIVERY OF GLUCOSAMINE SULPHATE: FORMULATION, CHARACTERIZATION AND PERFORMANCE EVALUATION

Arvind Sharma* , Sandeep Arora

ABSTRACT

Background:-Oral glucosamine sulfate (GS ) is marketed as a treatment of osteoarthritis. Since drug has short half life of 1 hr, dosage regimen of (GS ) is 500mg TDS. In bid to reduce the frequency of dosing and to improve patient compliance, a sustained formulation of glucosamine (GS ) is desirable. The purpose of this research was to study whether the bioavailability of Glucosamine could be improved by administering drug entrapped in fatty acid vesicles (FAV) topically Methods :- FAV were developed using rota evaporater followed by ultrasonication. Particle size and zeta potential were measured by photon correlation spectroscopy. Preformulation studies of different FAV formulations were carried out along with in-vivo studies in rats. Results:- Stable FAV formulation having a mean size range of 100 to 150 nm and a zeta potential range of –20 to –23 mV were developed. More than 60% of the drug was entrapped in the FAV. In vitro performance studies showed sustained release and stability of FAV. The muscle to plasma concentration ratio for niosomal gel formulation was six and for carbopol gel it was one Plain gel showed insignificant improvement whereas drug loaded FAV showed 25% remission in inflammation after the 15th day and 51% at the end of study (28th day)Conclusion:- Based upon these results it can be serve as ideal carrier as alternate for topical delivery of Antiarthritic drug.

Keywords: Anti-arthritic drug, oleic acid vesicle.