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Abstract

FORMULATION AND EVALUATION OF TENOFOVIR ORODISPERSIBLE TABLETS BY USING DIFFERENT SUPER DISINTEGRANTS

Sunitha Reddy*, Anusha Golla

ABSTRACT

Orodispersible tablets are gaining popularity over conventional tablets due to their convenience in administration and suitability for patient. The present study deals with the formulation of Orally disintegrating tablets of tenofovir disproxil fumarate using different super disintegrants. Orally disintegrating tablets of tenofovir disproxil fumarate was prepared using three super disintegrants namely crosscaramellose sodium, crosspovidone, sodium starch glycolate with the concentrations (1%,3%,5%) were prepared by direct compression method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density, and compressibility index. All the formulations were evaluated for weight variation, thickness, disintegration time, dissolution, hardness, friability, wetting time and water absorption ratio. All formulations possessed with good disintegration properties with average disintegration time of 29 to 39 seconds. The formulation F6 showed lowest disintegration time and more water absorption ratio. In vitro dissolution studies revealed that formulation f6 showed 98.7% percent drug release at the end of 20 minutes. These results revealed that the formulation F6 containing crosspovidone (5% )as super disintegrant was better one which satisfied all the crieteria as a orally disintegrating tablet.

Keywords: Orodispersible tablet, super -disintegrant, direct compression,anti-HIV.


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