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Abstract

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF TRAMADOL HYDROCHLORIDE FOR BUCCAL ADMINISTRATION

٭Yogananda. R, RakeshBulugondla, Nagaraja TS, Snehalatha, Lakshmiradhika G, Bharathi DR

S.J.M College of Pharmacy, Chitradurga, Karnataka, INDIA.

ABSTRACT

In the present study an attempt was made to formulate mucoadhesive buccal patches of Tramadol hydrochloride using various concentrations of chitosan and PVP K-30 polymers by solvent casting technique. FTIR spectroscopy revealed that there is no interaction between Tramadol hydrochloride and polymers. The formulated patches were evaluated for their physicochemical parameters like thickness, weight variation, surface pH, content uniformity, folding endurance swelling percentage studies and in vitro residence time. In vitro release studies were performed with pH 6.8 phosphate buffer solution. Data of In vitro release were fit into different equation and kinetic models to explain release kinetics. The kinetic models used were zero order, first order, higuchi’s and Korsmeyer Peppa’s model. The best mucoadhesive performance and matrix controlled release was exhibited by the formulation R6. Accelerated stability studies were carried out for three months and formulations found stable to that period of time. The formulation was found be right and suitable candidate for the formulation of Tramadol HCL mucoadhesive buccal patches for therapeutic use.

Keywords: Tramadol HCl, Chitosan, Mucoadhesivebuccal patches, PVP K-30.


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