Abstract

SYNTHESIS AND ANTI OXIDANT ACTIVITY OF N1-(4-FORMYL PHENYL)-5-(4-HYDROXY PHENYL)-1H-PYRAZOLE-3-CARBOHYDRAZIDE.

P. R. Logesh Kumar* and Dr. S. Vijayakumar

ABSTRACT

Pyrazoles are important class of heterocyclic compounds possessing interesting biological and Pharmacological properties as anti-inflammatory, anti-cancer, anti-bacterial, anti-viral, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, anticonvulsant, anti-diabetic and anti-fungal agents. Pyrazolines obtained by cyclization of chalcones with arylhydrazines, can be easily oxidized to pyrazoles. The compounds containing a pyrazole scaffold have been shown to exhibit HIV-1 reverse trancriptase inhibition, as well as anti hyperglycemic, antibacterial, sedative-hypnotics, anti-inflammatory, antipyretic and analgesic activity.

Keywords: Pyrazole, p-hydroxy acetophenone, spectral analysis, anti oxidant.