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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR THE ESTIMATION OF NISOLDIPINE IN PURE AND FORMULATIONS

K. Kamala*, M. Rama Krishna, D. Jeevanmani Babu, M. Nagendra Babu and N. Anil Kumar

ABSTRACT

A simple, precise, rapid and accurate gradient HPLC method has been developed for the estimation of Nisoldipine in bulk and tablet formulations. The chromatographic separation was achieved on Phenomenex C18 (250 mm x 4.6 mm, 5.0 μm) column using the mobile phase composed of acetonitrile : methanol in the ratio of 50:50 (v/v) at a flow rate of 1 mL/min and Nisoldipine was eluted at 3.340 min. Quantification and linearity was achieved at 237 nm within the concentration range of 10-80 μg/ml. The method was validated for specificity, linearity, accuracy, precision, LOD and LOQ as per the ICH guidelines and was found to be suitable to be employed in quality control.

Keywords: RP-HPLC, validation, nisoldipine and tablets.

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