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Abstract

AN EFFICIENT ONE-POT MULTI COMPONENT SYNTHESIS OF PYRIMIDINE AND THEIR ANTIMICROBIAL ACTIVITY

Mohammad Ashid and Ajit Joshi*

ABSTRACT

One pot three component synthesis of 4-amino/mercapto-6-(3-nitrophenyl)-2-sulfanylpyrimidine-5-carbonitrile (IVa-b) in moderate to high yield is achieved via a one pot synthesis reaction ofmalononitrile, substituted aromatic aldehyde & Guanidine/thiourea in ethanol. Which is further treated with formic acid to give final via Cyclization 7-Substituted-5-(3-nitrophenyl)pyrimido[4,5-d] pyrimidin-4(3H)-one (V a-b) in condensation process. All the synthesized compounds were supported by spectral and analytical analysis. Also the synthesized compounds were tested for their antimicrobial activity.

Keywords: Malononitrile, Thiourea, Guanidine, Pyrimidine, Tetrazolopyrimidine, s-Triazolopyrimidine.


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