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Abstract

HYPOGLYCEMIC ACTIVITY OF MEMECYLON UMBELLATUM LEAVES METHANOLIC EXTRACT

Ravindra Puttaswamy, Peethambar S.K. and Rajeshwara N. Achur*

ABSTRACT

Objective: To evaluate the hypoglycemic potential of methanolic extract of Memecylon umbellatum leaves. Methods: The methanolic extract was prepared by successive Soxhlet extraction with solvents of varying polarity. The diabetes was chemically induced in Swiss albino rats by a single dose of alloxan (120mg/kg, i.p.). After the development of diabetes, methanolic extract of the leaves was administered (i.p.) at two different concentrations (75 and 150mg/kg) and analyzedthe change in sugar level. Acute toxicity studies were performed by checking the altered levels of urea, creatinine, serum glutamate oxaloacetate transaminase (SGOT), and serum glutamate pyruvate transaminase (SGPT). Results:The administration of methanolic extract of the plant resulted in significant reduction of blood glucose level (p<0.001) in diabetic rats. The acute toxicity studies revealed no side effects on the liver and kidney as evident by the level of urea and creatinine. The extract exhibited significant reduction in urea and creatinine level (p<0.001) as well as SGPT and SGOT values (p<0.01) as compared to diabetic control. The chronic studies confirmed a gain in body weight of the extract administered rats as compared to diabetic controls (p<0.01). Conclusion: Our studies indicate that M. umbellatum, an endangered medicinal plant from the Western Ghats of Karnataka, possesses a very good hypoglycemic activity. Isolation, purification and identification of the active ingredient present in the methanolic extract should reveal the usefulness of this molecule for further detailed studies and commercial exploitation.

Keywords: Memecylon umbellatum, antidiabetic activity, alloxan, medicinal plant.


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