Abstract

TOPICAL LIPOSOMAL GEL: A NEW STRATEGY OF NOVEL DRUG DELIVERY

Susanta Paul*, Mayukh Jana, Anannya Bose, Sunirmal Bhattacharjee, Joyeeta Guha Roy and Puja Chakraborty

ABSTRACT

Liposomes established themselves as a promising novel drug delivery vehicle in several different basic sciences and as a viable alternative in several applications. Liposomes are microscopic spheres with an aqueous core surrounded by one or more outer shells consisting of lipids arranged in a bilayer configuration. Liposomes are acceptable and superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. It also has affinity to keratin of horny layer of skin and can penetrate deeper into skin and hence give better absorption. Applied on the skin, liposomes may act as a solublizing matrix for poorly soluble drugs, penetration enhancer as well as local depot at the same time diminishing the side effects of these drugs. Topical liposome formulations could be more effective and less toxic than conventional formulations. The liposome gel formulations could perform therapeutically better effects than the conventional formulations, as prolonged and controlled release topical dosage forms, which may lead to improved efficiency and better patient compliance.

Keywords: Liposomal gel, novel drug delivery, topical application.