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Abstract

NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 7-SUBSTITUTED 1-CYCLOPROPYL-6 -FLUORO-1, 4-DIHYDRO-8-METHOXY-4-OXOQUINOLINE-3-CARBOXAMIDE DERIVATIVES

Zaki Ahmed B. Munshi, Bhikan J. Khairnar, Dhananjay V. Mane
Bhata R. Chaudhari*

ABSTRACT

Here in we report synthesis of 1-cyclopropyl-6, 7-difluoro-1, 4-dihydro-8-methoxy-4-oxoquinoline-3-carboxamide. The target compound was synthesized from 1-cyclopropyl-6, 7-difluoro-1, 4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid by one pot synthesis using simple reagent and condition. Then different novel derivatives of 7-substituted 1-cyclopropyl-6 -fluoro-1, 4-dihydro-8-methoxy-4-oxoquinoline-3-carboxamide were synthesized by substituting fluoro group at C-7 position with different cyclo amine or cyclo amine with different hetero atoms. The novel synthesized compounds were characterized then examined for their antibacterial and antifungal activities.

Keywords: Antimicrobial, Quinoline-3-carboxamide, Moxifloxacin, Gatifloxacin, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride and 1-Hydroxybenzotriazole.


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