Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

FORMULATION AND IN VITRO EVALUTION OF MATRIX TABLET CONTAINING SILDENAFIL CITRATE

*Ashish bhandari1, Seema Gosain2, Ganesh Kumar Bhatt1, Preeti Kothiyal1

1Shri Guru Ram Rai Institute of Technology & Science P.O. Box - 80, Patel Nagar, Dehradun 248001, Uttarakhand , India.
2Dehradun institute of technology, Mussourie-Diversion Road, Makkawala, Dehradun, Uttarakhand-248009, India.

ABSTRACT

Sildenafil citrate is a selective inhibitor of phosphodiesterase type 5 enzyme (PDE5), it offers potential to treat patients with pulmonary hypertension by selectively inhibiting phosphodiesterase type five pathways in the lung. It is recommended for selected patients with pulmonary arterial hypertension, and has favourable effects on endothelial function. Controlled release matrix tablets of Sildenafil citrate is designed by simplex lattice design and evaluating the relationship and influence of different content levels of HPMC (Hypromellose), Eudragit L100 and Carbopol (Carbomer), in order to achieve a zero-order release of Sildenafil citrate. Tablets were prepared by wet granulation process and evaluated for different pre and post compression parameter, from these matrix tablets drug release was prolonged, leading to achieve an effective therapy with low dosage of the drug, to reduce the frequency of medication.

Keywords: Sildenafil citrate, Pulmonary hypertension, Matrix tablet, HPMC, Eudragit, controlled release.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More