Abstract

METHOD DEVELOPMENT AND DETERMINATION OF RISEDRONATE SODIUM IN PHARMACEUTICAL DOSAGE FORMS BY VISIBLE SPECTROPHOTOMETRY

P. V. Lakshmana Rao and C. Rambabu*

ABSTRACT

Two simple, accurate and economic spectrophotometric methods A and B were developed for the determination of Risedronate sodium in bulk and dosage forms. These methods are based on the formation of chloroform soluble ion-associates in the presence of acidic dyes namely BPB (Method A) and BCP (Method B) exhibiting max at 420 and 416 nm respectively. These methods obey Beer’s law in the concentration range of 2.0-10.0 μg/ml and 2.0-10.0 μg/ml. The molar absorptivities are found to be 1.82x104 and 2.49x104 lt/mol.cm for methods A and B. These methods are found to be suitable for the assay of Risedronate sodium in pharmaceutical formulations.

Keywords: Risedronate sodium, BPB, BCP, Spectrophotometry.