Abstract

PROTECTIVE EFFECT OF APIUM GRAVEOLENS, CINNAMOMUM VERUM IN CCL4 INDUCED MODEL OF ACUTE LIVER INJURY

Faruk H. Al-jawad, Haitham M. Kadhim*, Muayyad S. Abbood and Nada I. Salman

ABSTRACT

Objective: The present study was designed to determine the hepatoprotective effect of Apium Graveolens(celery) ,Cinnamomum verum(Cinnamon) in acute lever injury induced by hepatotoxic agent CCL4. Materials & methods: the normal serum values of ALP, AST, ALT, TSB &TSP were determined in 32 healthy domestic rabbits before CCL4 induction &at two occasions 24,120hrs after ALI induction by CCL4 and treatment with aqueous extract of herbs for five successive days. Results: showed significant decrease in ALP, AST&TSB level of both aqueous extracts measured at 120hr compared with control group &their levels measured at 24hr. conclusion: Both extract of celery & cinnamon possess mild hepatoprotective effect which was more powerful in the first extract. The histopathological examination showed a clear improvement in the sections of the liver tissue that support the effect of these aqueous extract on the liver.

Keywords: Apium Graveolens(celery), Cinnamomum verum(Cinnamon), ALI,Hepato protection.