Abstract

SYNTHESIS OF PYRIMIDINE BASED THIAZOLE HYBRIED FOR EVALUATION OF THEIR ANTICANCER ACTIVITY

Dr. Kushal R. Lanjewar*

ABSTRACT

New series of 5-(2-aminothiazol-4-yl)-3,4-dihydro-4-phenyl pyrimidin-2(1H)-ones are reported. Efficient cyclocondensation of appropriately substituted 5-(2-bromoacetyl)-3,4-dihydro-4-phenylpyrimidine-2(1H)-ones with thiourea in ethanol gives high yield to furnish the corresponding thiazoles. Dihydropyrimidine carboxylates and their bromo derivatives were the key substrates for cyclocondensation. The series of 5-(2-aminothiazol-4-yl)-3,4-dihydro-4-phenyl pyrimidin-2(1H)-ones revealed biological activity as anticancer against the 60 cell panel at five concentration levels.

Keywords: Pyrimidines, bromopyrimidines, thiazoles, cyclocondensation reaction, anti-cancer activity.