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  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

FORMULATION AND EVALUATION OF AN ION ACTIVATED IN SITUGEL FOR OCULAR DELIVERY OF NORFLOXACIN

Kinjal B. Rathod *, Mandev B. Patel

ABSTRACT

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an anti-bacterial agent- Norfloxacin, based on the concept of an ion activated in situ gelation. Sodium alginate was used as the gelling agent in combination with Hydroxy Propyl Methyl Cellulose (HPMC K4M) which acted as a viscosity enhancing agent. The prepared formulations were characterized for clarity, pH, drug content, viscosity, gelling capacity, in vitro drug release, antimicrobial efficacy, ocular irritation and stability. The clarity, pH viscosity and drug content of the developed formulation were found to be satisfactory. The developed formulation was therapeutically efficacious, stable, non-irritant, and provided sustained drug release over an 8-h period. The developed formulation is a viable alternative to conventional eye drops by virtue of its ability to enhance bioavailability through its longer precorneal residence time and ability to produce sustained drug release. Also important factor is the ease of instillation and the reduced frequency of instillation resulting in better patient acceptance.

Keywords: In situ gelling, sodium alginate, norfloxacin, antimicrobial efficacy.


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