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Abstract

LIPOPROTEIN(a) AND LIPID LEVELS IN CHILDREN WITH AND WITHOUT FAMILY HISTORY OF PREMATURE ISCHEMIC HEART DISEASE

Dr. Jusmita Dutta*, Dr. Ummed Singh Solanki

ABSTRACT

Cardiovascular disease (CVD) is the number one cause of death globally. The incidence of Coronary Artery Disease (CAD) in the young has been reported to be 12%–16% in Indians. Half of the CVDrelated deaths (ie 52% of CVDs) in India occur below the age of 50 years, and about 25% of acute myocardial infarction (MI) in India occurs under the age of 40 years. Multiple studies have demonstrated that atherosclerosis has its silent beginning during childhood. The importance of cardiovascular risk factors like hypertension, obesity and dyslipidemia in prediction of latent CAD in offspring of parents with Ischemic Heart Disease (IHD) are well known. New risk factor, such as lipoprotein (a) has been identified and is under further investigation. This study was aimed to identify the children with high risk of IHD in terms of dyslipidemia and Lp(a) levels so that appropriate measures can be taken early in life to prevent or delaying the IHD. Total 90 subjects (children) were included in the study. The subjects were divided into 2 groups, group A and group B. Group A consisted of 45 offspring of cases of premature ischemic heart disease and 45 age sex matched healthy children served as group B. Lp(a) levels were estimated by in vitro turbidometric immunoassay using a kit.. It was seen that mean level of Total Cholesterol, Triglyceride, Very Low Density Lipoprotein-Cholesterol and Low Density Lipoprotein-Cholesterol were significantly higher in children with family history of premature ischemic heart disease as compared to group B children. Taking 30 mg/dl as the cut off value of Lp(a), majority of children with familial history of IHD had significantly higher levels (P<0.001) when compared to group B children. We conclude that children of ischemic heart disease patients have significant incidence of dyslipidemia compared to age sex matched healthy children. Therefore, all these children should be screened for dyslipidemia, and dietary measures should be applied as a first step approach. The strong genetic component of lipoprotein (a) in association with its atherogenic potential favours its determination in children with a family history of premature ischemic heart disease.

Keywords: Lipoprotein (a), Ischemic heart disease, Lipids, Coronary artery disease.


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