Abstract

REVIEW ON STATINS INDUCED TYPE II DIABETES MELLITUS

Naseem Shifafiya M., Jayaseelan S.* and Sambath Kumar R.

ABSTRACT

The purpose of the study is to review about the occurrence of Type II Diabetes Mellitus as a outcome of statin therapy. Statins are generally prescribe for Lipid lowering agents, which are described to eliminate cardiovascular disorders mortality and morbidity. However, modern scientific trials have observed as statins are reason for occurring worsening effect mainly elevated blood glucose levels and increase the occurrence of newly diagnosed diabetes. The relation between the diabetogenic mechanism of statins with intensive dose and occurring key threatening factors for new arrival diabetes have be identified. However, statins may possibly not have any unpleasant effect on insulin sensitivity in non diabetic patients. Reason for affective mechanisms has determined to be how the use of statins can cause peripheral insulin resistance and β-cell insulin secretory dysfunction prominent to occurrence of diabetes. According to result from these recent clinical trials, the benefits of usage of statin administration cause more risk of emerging new onset diabetes. Therefore, it would be required to discontinue the administration of lipid lowering agents for the safety of cardiovascular disease because of its possible risk for increasing new onset diabetes. Higher potency statin administration is used with a modest surge in the threat of occurrence of new onset diabetes related with lower potency statins in patients administered for promotion of cardiovascular complication as well as cerebrovascular complication. Clinicians should regard as this risk when prescribing higher potency statins used for secondary prophylaxis. This review concluded that if the patient who are taking statin therapy have developing serious risk of occurrence of event diabetes mellitus as curse to clinical perspective.

Keywords: Statins, New onset diabetes, Diabetogenic effect, cardiovascular disease.