Abstract

COMPARATIVE STUDY BETWEEN TWO MARKETED AMOXICILLIN/CLAVULANIC ACID BRANDS IN KINGDOM OF SAUDI ARABIA

Dr. Ibrahim A. Maghrabi

ABSTRACT

Oral administration of pharmaceuticals is one of the most popular methods of drug Delivery. The combination of the amoxicillin and clvulanic acid is widely use in prescriptions in Kingdom of Saudi Arabia, This research aimed to study the effect of two marketed brands Augmentin and Amoclan and compare them with standard pure drug, also this study as post market monitoring of the drugs in community pharmacies. The microbiological sensitivity test was done against both gram positive and gram negative in (Escherichia coli, Salmonella typhi, Salmonella para typhi and Staphylococcus aureus). Both of drugs were given clear inhibition zone with more effect for Augmentin, this due to high distribution of active ingredient in Augmentin than Amocalan in formulation process or might be due to distribution of additives.

Keywords: Tablets, Amoxicillin/clavulanic acid, Bacteria, Sensitivity Test, Inhibition Zone.