Abstract

TO STUDY THE EFFECT OF SILYMARIN AGAINST LIPOPOLYSACHHARIDES INDUCED NEUROINFLAMMATION IN MICE

Priyanka Sonker*, Talha Jawaid, Polly Gupta, Kalpana and Rajan Awasthi

ABSTRACT

Aim of the study: To study the effect of Silymarin against Intracerebral (i.c.) LPS induced Neuroinflammation in mice. Material and methods: The effect of Silymarin was examined against Intracerebral (i.c.) LPS induced Neuroinflammation in mice. The behavioural study was performed by using models Morris water maze. Various biochemical parameters such as proinflammatory cytokines (TNF-α) as indicator of Neuroinflammation, Acetyl cholinesterase (Ach E) activity as marker of cholinergic activity and malonaldialdehyde ( MDA) and glutathione (GSH) as marker of oxidative stress were estimated. LPS was used in dose of (5μg/5μl) for Neuroinflammation in mice was used. Silymarin was administered in two different doses of 25mg/kg and 50mg/kg. Result: Silymarin exhibit a significant (p

Keywords: Silymarin, LPS, MDA, GSH, Ach E, Intracerebral (i.c.) and Latency time (LT).