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Abstract

STUDY OF DIFFERENT SUPER DISINTEGRANTS ON SOLID DISPERSED ETORICOXIB TABLETS EMPLOYING PGS-PVP-AEROSIL CO PROCESSED EXCIPIENT AS DIRECTLY COMPRESSIBLE VEHICLE

K. V. N. R. Aishwarya*, Md. Muneera Nasheen, M. N. L. Sravya, N. Vijay Kumar, N. Vimala Rani and N. Divya Supriya

ABSTRACT

The objective of the present study is to prepare and characterize a new co-processed excipient namely pre-gelatinized starch – PVP K30– Aerosil (PGS-PVP-Aerosil) and to evaluate its application as a carrier in solvent deposited (SD) dispersions for enhancing the dissolution rate of a poorly soluble BCS class II drug namely etoricoxib from SD dispersions and their tablet formulations.SD dispersions of etoricoxib in PGS-PVP-Aerosil were prepared by kneading method. Proportion of drug: excipient 1:1 was used to prepare SD dispersions.Tablets of etoricoxib were prepared employing SD dispersions in PGS-PVP- Aerosil by using two different disintegrants such as Crosscarmellose sodium and sodium starch glycolate by wet granulation method and were evaluated for drug content, hardness, friability, disintegration time and dissolution rate. The SD dispersions prepared were fine, discrete and free flowing powders. A SD dispersions in PGS-PVP-Aerosil could be formulated into tablets by direct compression method and the resulting tablets fulfilled the official specifications with regard to drug content, hardness, friability and disintegration time. All the tablets prepared disintegrated rapidly within 3-5min and gave rapid dissolution of the contained drug,etoricoxib. Etoricoxib tablets formulated employing Crosscarmellose sodium fulfilled the official (IP 2010) dissolution rate specification of NLT 70% in 45 min prescribed for etoricoxib tablets. The dissolution rate of Etoricoxib could be markedly enhanced by solvent deposition on the new co-processed excipient (PGS-PVP-Aerosil) developed. SD dispersions of etoricoxib in the new co-processed excipient (PGS-PVP-Aerosil) could be compressed into tablets retaining their fast dissolution characteristics. Etoricoxib tablets prepared by employing Crosscarmellose sodium gave better disintegration and dissolution than Sodium starch glycolate.

Keywords: Co-processing, Excipients, Etoricoxib, Solvent Deposition, Tablets, Dissolution Rate.


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