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Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE TABLETS OF AMBROXOL HYDROCHLORIDE

Murthy P. N. V. N.* and Anand Kumar Y.

ABSTRACT

Oral drug delivery is the leading and the oldest form of all drug delivery systems in the market. It is the greatest growing and most favored route for drug administration so, oral controlled release of drugs becomes a very promising approach for drugs which are having shorter half-life and high dose frequency. Matrix tablets are an interesting option and new breakthrough when developing an oral controlled release drugs delivery system. In the present investigation controlled release matrix tablets of Ambroxol HCl were prepared using Na CMC, Xanthan gum, HPMC100cps, Ethyl Cellulose (15cps), Compritol, Precirol in different concentrations for the treatment of bronchial disorders. Various tablet formulations were prepared and evaluated for compatibility studies and physical parameters such as Hardness, Friability, Dissolution, Content Uniformity and Thickness. The manufacturing procedure was optimized with respect to the hardness 5 to 6 kg/cm2 and description being white, round shaped tablets with flat face on both sides. The tablet weight was targeted for 260 mg. The developed formulations showed uniform pre and post compresssional properties. Out of all formulations F5 was showed higher rate of drug release 99.46 % when compared to other formulations. Formulation containing NaCMC, Xanthan gum, HPMC100cps polymers showed higher rate of drug release over a period of 24hrs. In conclusion, the results suggest that the developed controlled release matrix tablets of Ambroxol HCl is a potential attempt, and better than conventional dosage forms, leading to avoid dosing frequency and better patient compliance.

Keywords: Ambroxol HCl, Precirol, Sodium CMC and controlled release.


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