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Abstract

IMPACT OF FORMULATION PARAMETERS ON FAST DISSOLVING TABLET OF ONDANSETRON HYDROCHLORIDE PREPARED BY PRESSURIZED HOMOGENIZATION TECHNIQUE

Sachin S Salunkhe*, Neela M Bhatia, Prathamesh A Kulkarni, Apurva S Kale,Unmesh E Pagar, Manish S Bhatia

ABSTRACT

The demand for fast dissolving tablets of OndansetronHCl has been growing during the last decade especially for the geriatric and pediatric patients. OndansetronHCl is a recognized as antiemetic drug, so development of an FDT OndansetronHCl and to evaluate the effect of various concentrations of superdisintegrant and binder on its disintegration time and release profile was the prime objective of this research work. Methods: Tablets were prepared by high pressure homogenization followed by direct compression.22 factorial design was applied in which concentration of superdisintegrant and binder were taken as independentvariables and disintegration time and percentage release were taken as dependent variables. The prepared tablets wereevaluated for weight variation, hardness, friability, disintegration time, content uniformity, and % drug release. Direct compression process was selected for this formulation of ODT tablets, because porous nature is more in direct compression blend than wet granulation blend, so tablet will facilitates for faster disintegration and dissolution. Results: The optimised batch of fast dissolving tablet of Ondansetron hydrochloride prepared by pressurized homogenization using taste masking polymer Eudragit E-100 complies for all evaluation tests as per Indian Pharmacopoeia and applied statistical design was found to be significant. Conclusions: It was concluded that pressurized homogenization technique is a useful method forpreparing fast dissolving tablets of ondansetron followed by direct compression.

Keywords: Fast dissolving tablets; superdisintegrants; ondansetron; direct compression; factorial design.


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