Abstract

DRUG INDUCED LIVER INJURY: A REVIEW ARTICLE

*Syed Ayathullah, Meenaz Asfin and Sravya Teddu

ABSTRACT

Drug-induced liver injury (DILI) is an important differential diagnosis in many patients in clinical hepatology. DILI is the primary cause of acute liver failure and is an important safety issue when new drugs are developed. The prime clinical presentation is acute hepatitis and/or cholestasis, even though almost any clinical pathological pattern of acute or chronic liver disease can occur. The pathogenesis of drug-induced liver disease usually involves the involvement of the parent drug or metabolites that either directly affect the cell biochemistry or elicit an immune response. Each hepatotoxin is associated with a characteristic signature regarding the pattern of injury and latency. However, some drugs may exhibit signature. Recent and future advances in toxicogenomics and proteomics should improve the identification of risk factors and the understanding of idiosyncratic hepatotoxicity.

Keywords: Drug induced liver injury, NSAIDS, Acetaminophen, Antibiotics.