Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

FORMULATION AND OPTIMIZATION OF NANOSTRUCTURED LIPID MATRICES OF REPAGLINIDE USING FACTORIAL DESIGN

Maulik P Talsania, GS Shantha Kumar*, Divakar Goli, Roopa Karki,Venkatesh DP

ABSTRACT

The purpose of the present research work was to overcome the poor solubility of repaglinide, reduce dosing frequency and increase the bioavailability by formulating repaglinide nanostructured lipid matrices and subject the formulation for optimization by using factorial design. Repaglinide, an antidiabetic drug is used for the management of type II diabetes mellitus. It is practically insoluble in water and undergoes hepatic first pass metabolism and hence shows bioavailability of 56%. It is having short half-life of 1 h. Repaglinide NLCs were formulated by using different lipid: co-emulsifier ratio and surfactant ratio using factorial design. Prepared repaglinide nanostructured lipid carriers were characterized for FT-IR study, DSC study, entrapment efficiency, in vitro drug release, particle size analysis, SEM study, zeta potential, polydispersity index, in vivo antidiabetic study and stability studies. FTIR and DSC studies showed there is no interaction of drug with lipids and polymers. Average particle size was found to be in the range of 10.38 to 200.68 nm. SEM studies revealed that particles were irregular in shape and rough in nature. Zeta potential was found to be in the range of -28.65 to -58.32 mV showed good stability of NLCs. Highest entrapment efficiency and cumulative drug release of 85.460.041% and 86.160.45% was predicted. In vivo antidiabetic study for blood glucose level showed an effective marked decrease in blood glucose level of repaglinide NLCs (F6) on 3rdand 7th day as compared to repaglinide standard. The results showed no or little change in entrapment efficiency and cumulative drug release before and after stability studies.

Keywords: Repaglinide, lipid, nanostructured lipid carrier, zeta potential, Blood glucose level, polydispersity index.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More