Abstract

STRUCTURE BASED DRUG DESIGN ASPECT OF SCHIFF BASE LINKED WITH OSELTAMIVIR ANALOGUES AS NEURAMINIDASE INHIBITORS

Mukesh Kumar Gupta*, J. S. Dangi, Vijay Kumar Patel and Kiran S.

ABSTRACT

Neuraminidase enzymes are the common surface protein which preset in influenza, some bacteria, fungi, protozoan and animal cell surface. They are the powerful target for the antimicrobial drugs against the respiratory disease. The analogues of resistant oseltamivir is the main aim for designing novel ligands with the help of molecular modelling technique. Schiff base moieties link with C-3 of 4-acetamido-3-aminobenzoic acid give the novel drug design against the microbial neuraminidase binding site. The interactions of these analogues with neuraminidase have been probed by Structure-based drug design. The SAR study show that Schiff bases with methoxy, hydroxyl and nitro aldehydes prove good inhibitor with target and also these compounds gives good activity against the bacterial and fungal neuraminidase. In this research we evaluate the novel oseltamivir analogues contains imine base for antimicrobial action which may treat respiratory disease.

Keywords: Acetamido-benzoic acid, Neuraminidases, Oseltamivir, Schiff base, Structure-based drug design.