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Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW HETEROCYCLIC GUANIDINE DERIVATIVES

Bhupender Singh Rawat*, S.C Mehra and Roopali Tandon

ABSTRACT

A wide range of thiazole, oxazole and thiadiazole /oxadiazole heterocyclic derivatives has been studied for various biological activities. heterocyclic moieties has been found in a large number of compounds which shows antibacterial, antifungal, anti-inflammatory, antituberclosis, anticonvulsant activity. There is a close relation between the biological activity of the compounds on their molecular structures. The compounds containing thiazole, thiadiazole, oxazole, oxadiazole, imidazole, pyrimidine, pyridine & benzothiazole rings have been found to exhibit broad spectrum of biological activities. The aim of the present study was to design, synthesize, and evaluate novel antibacterial agents, derivatives of 1-[2`(thiazo- oxazolyl)]-1,3-dialkyl-4-(2`oxazolyl) Guanidine. The synthesized compounds were investigated against Staphylococcus aureus, B.subtilis & Micrococcus luteus (gram positive bacteria), P. Aeruginosa, E.coli & Citrobacter freundii (gram negative bacteria) for antibacterial study.

Keywords: Thiadiazole, Oxadiazole, Guanidines, Antibacterial, Gram positive, Gram negative.


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