World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , Indian Science Publications , SOCOLAR, China , NewJour-Georgetown University Library, USA , eGranary Digital Library, USA , CAS (A Division of American Chemical Society) USA , VIKAS PSOAR (Pharmaceutical Sciences Open Access Resources) , Urlich's Periodicals Directory, Proquest, UK , AYUSH RESEARCH PORTAL , Scopus ((Elsevier Products in process) , EMBASE (Elsevier Products, in process) , EBSCO Publishing Inc (Academic Search Complete, USA, In Process) , Genamics JournalSeek (In Process) , Kaohsiung Medical University Library (In Process) , OurGlocal (In Process) , eSci Research, International Research Organization. , Geneva Foundation for Medical Education and Research, Switzerland (In Process) , Thomson Reuters, USA (in process) , Polish Scholarly Bibliography , Virtual Library Pharmacy, Medicine and Health, Biosciences , Global Impact Factor (0.629) , UDLedge Science Citation Index , International Impact Factor Services , Directory of Research Journal Indexing (DRJI) , Universal Impact Factor (1.0408) , International Scientific Indexing, UAE , SJIF - Scientific Journal Impact Factor (2.786) , Scholar Steer, (Under Process) , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , InfoBase Index (In Process) , Scholar Article Impact Factor, SAIF , Citations Impact (Under Process) , CiteFactor , Journal Index (JI, Under Process) , Indian citation Index (ICI) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Eurasian Scientific Journal Index (ESJI) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Journalseek Database , IP Indexing (IP Value 2.76) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , International Scientific Indexing ( ISI ) , Scope Database , Open Access Journal , Academia , Doi-Digital Online Identifier , ISSN National Centre , Zenodo Indexing , International CODEN Service, USA ,

World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

Login

Search

News & Updation

Updated Version

WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

Call for Paper

WJPPS Invited to submit your valuable manuscripts for Coming Issue.

Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SIMVASTATIN AND EZETAMIB IN BULK DOSAGE FORM BY UPLC METHOD

Mannem.Anithakumari*, Dhanalakshmi.K.Nagarjuna Reddy.G

ABSTRACT

Objective: A new, simple, rapid, sensitive, precise, accurate and effective UPLC method has been developed and validated for the analysis of Simvastatin and Ezetamib in bulk and tablet dosage formulation as per United States of pharmacopeia (USP) guidelines. In UPLC, the Chromatographic separation was achieved on Aquity UPLC BEHphenyl 1.7μm *2.1mm,100mm and the detection wave length at 230 nm using a mobile phase of 1g orthophosphoric acid,100% methanol, pH was adjusted to 3 with 0.1N NaoH. In UPLC, the retention time for Simvastatin was found to be 4.755 ± 0.21 min. Linearity was observed in the concentration range of 25-150mcg with a correlation coefficient 0.9998. The % RSD value for precision was found to be 1.41 and the mean recovery was found to be 99.99. And EZETAMIB was found to be 3.183min. The amount of drug estimated was found to be in good agreement with label claim. The method was validated and found to be simple, sensitive, accurate and precise as per USP guidelines by UPLC.

Keywords: USP, UPLC, Simvastatin.

[Download Article] [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Downloads

Author Instruction

Covering Letter

Copyright Form

Apycom jQuery Menus