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Abstract

DESIGN DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF SALBUTAMOL WITH NATURAL POLYMER

Gururaj S. Kulkarni 1a, b, N.G Raghavendra Rao2*

1a Research Scholar of Singhania University, Rajasthan, India
1b Dept of Pharmaceutics, Vivekananda college of Pharmacy, Bangalore - 56055, KS, India.
2*Dept of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Karimnagar, 505481, India.

ABSTRACT

The objective of this work is to improve the bioavailability of salbutamol has first pass metabolism and poor bioavailability by oral administration. When we develop a novel drug, delivery dosage forms few points should be considered before deciding the new dosage form. They are reduction in dose, contra indications, adverse effects and dose frequency. Buccal mucosa is an attractive route for systemic delivery of many drugs since it is relatively permeable with a rich blood supply. In the present work, Mucoadhesive tablets of salbutamol are prepared by using natural polymer xanthan gum in various concentrations. Salbutamol is one of the old and most commonly used anti-asthmatic drug, is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. Salbutamol Mucoadhesive tablets were prepared by direct compression. Powder blend were evaluated for pre-compressional parameters. The prepared tablets evaluated for post-compressional parameter like weight variation, thickness, hardness, and friability, surface pH, mucoadhesive strength, in vitro drug release and Ex-vivo permeation study. The compatibility of drug with other ingredients was checked by FTIR studies. FTIR results revealed that there was no interaction between dug and other excipients. All the post-compressional parameter are evaluated were prescribed limits and results were within acceptable limits. The in vitro release study was carried out by using USP dissolution apparatus in pH 6.8 buffer. The release of salbutamol from all the formulations was in the range of 78.66 to 99.78 % at the end of 8 hrs. The results were revealed that the release of salbutamol buccal tablets was slower in formulation SX1 and SX2, may be due to the high concentration of Xanthan gum polymer, in comparison to other formulations. All the formulations showed the first order release. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. From this, study it can be concluded that, mucoadhesive tablets of salbutamol are prepared by using natural polymer provides controlled release of the drug. Hence improve the therapeutic effect of the drug by increasing its bioavailability.

Keywords: Salbutamol, xanthan gum, magnesium Stearate, mucoadhesive, permeation study, buccal tablets.


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