Abstract

EFFECT OF CHITOSAN: A REVIEW ON INFLAMMATORY BOWEL DISEASE

V. Mythili, O. S. Aysha* and S. Valli

ABSTRACT

Inflammatory bowel disease (IBD) is a major common disease appearing in some industrial countries like Asia, Africa, UK and Europe. Patients with IBD has increased rate of risk factors for developing colorectal cancer. Recent research into the utilization of metabolic activity and the colonic microenvironment in the lower gastrointestinal tract has attained a great value in the design of novel colon-targeted delivery system based on natural biodegradable polymers. This study examines the role of Nano particles in treating IBD. Chitosan plays an essential role in treating colitis with the incorporation of drug TNF α. The natural products having anti-IBD actions included phytochemicals, antioxidants, microorganisms, dietary fibers, and lipids. The literature revealed that many of these natural products exert anti-IBD activity by altering cytokine production. The anti-IBD effects of dietary fiber were mainly mediated via peroxisome proliferator–activated receptor-γ, TNF-α, nitric oxide, and IL-2, whereas the anti-IBD effects of lactic acid bacteria were reported to influence interferon-γ, IL-6, IL-12, TNF-α, and nuclear factor-κ light-chain enhancer of activated B cells.

Keywords: Chitosan, IBD, Ulcerative colitis, Immune cells, Drug carriers.