Abstract

PROTEIN & PEPTIDE DRUG DELIVERY: A FUNDAMENTAL NOVEL APPROACH AND FUTURE PERSPECTIVE

Sanjoy Das* and Asish Bhaumik

ABSTRACT

The protein and peptides are very important in biological cells. Lack of proteins and peptides causes diseases like Diabetes mellitus. Diabetes mellitus is caused due to the lack of protein called insulin. Now a day‟s r-DNA technology and hybridoma techniques also used in protein and peptide based pharmaceuticals. Proteins are the most abundant macromolecules in the living cells, occurring in all cells and all parts of cells. Cells can produce proteins that have strikingly different properties and activities, by joining same 20 amino acids in many different combinations and sequences. The term protein is used for molecules composed of over 50 amino acids, and peptide for molecules composed of less than50 amino acids. Scientific advances in molecular and cell biology have resulted in the development of two new biotechnologies. The first utilizes recombinant DNA to produce protein products. The second technology is hybridoma technology. Various proteins and peptides drugs are epidermal growth factor, tissue plasminogen activator. Management of illness through medication is entering a new era in which a growing number of biotechnology produced peptide and protein drugs are available for therapeutic use. Ailments that can be treated effectively by this new class of therapeutic agents include cancers, memory impairment, mental disorders, and hypertension. Proteins and peptides are widely indicated in many diseased states. Parenteral route is the most commonly employed method of administration for therapeutic proteins and peptides. This article summarizes the application of polymeric NPs for protein and peptide drug delivery following oral, nasal, pulmonary, parenteral, transdermal, and ocular administrations.

Keywords: Diabetes mellitus, Hybridoma, Epidermal growth factor, Plasminogen activator and Pulmonary etc.