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Abstract

FORMULATION AND IN VITRO EVALUATION OF EFFERVESCENT FLOATING MATRIX TABLET OF PROPAFENONE HCL

Chordiya Mayur Ashok*, Gangurde Hemant Hiraman, K. Senthilkumaran

ABSTRACT

Gastroretentive dosage forms have potential for use as controlledrelease drug delivery systems. The use of floating dosage forms is one method to achieve prolonged gastric residence times, providing opportunity for both local and systemic drug action. Propafenone HCl has a short elimination half-life, a narrow absorption window and is mainly absorbed in proximal areas of GIT. The purpose of this study was to develop a gastroretentive controlled release drug delivery system with floating properties of Propafenone HCl. Tablets were prepared by using controlled release polymers HPMC E5 and HPMC K100M. Floating matrix tablet contains sodium bicarbonate as a gas generating agent. The formulations were evaluated for pharmacopoeial quality control tests and all the physical parameters evaluated were within the acceptable limits. All formulations were evaluated for floating behavior, which showed good floating lag time and total floating time up to 12 h. Floating behaviour and In-vitro drug release studies were conducted in 0.1 N HCl (pH 1.2) at 37 0.5 C. Formulation F14 was proved to be good floating behavior, dimensional stability and drug release up to 12 h. Stability studies were carried out on the optimized formulation for period of 3 months at 400c/75 %RH. Finally it was observed that there was no change in physiochemical and physical properties as well as in drug release profile even after storage at 45 C and 75 % for three months.

Keywords: Propafenone HCl, dimensional stability, gastroretentive drug delivery system, floating dosage forms.


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