Abstract

THERAPEUTIC POTENTIAL OF AQUEOUS EXTRACT OF CITRON FRUIT INCREASES INHIBITION OF GASTRIC LESION IN EXPERIMENTAL RATS

*B Nagaraju¹, Dr. Sudhansu Ranjan Swain², DS Puranik³, GV Padmavathi⁴, SP Shampalatha⁵ and S Chincholi⁶

¹Medical Department (Pharmacy), South Western Railway Divisional Hospital, Bangalore 560023, India.
²Faculty of Pharmacy, MET Group of Institutions, MIT Campus, Ram Ganga Vihar, Phase - II, Moradabad-244001, India.
³Department of Pharmacology, Nargund College of Pharmacy,Bangalore 560085, India.
⁴Department of Medical Surgical Nursing, Hina College of Nursing, Bangalore 560064, India.
⁵Department of Community Nursing, Hina College of Nursing, Bangalore 560064, India. ⁶Regulatory Analyst, Regulatory Affairs, Aris Global, Mysore-570016, India.

ABSTRACT

The effect of Citron (Citrus medica Linn.) fruit aqueous extract on gastric ulcers was evaluated by using Indomethacin induced ulcer model in rats. Citron Fruit Aqueous Extract was administered orally at two different doses of 250mg/kg and 500mg/kg. Both the doses showed a significant reduction in ulcer formation and increase the inhibition of gastric lesions. The results suggest that, the fruits of Citron possess significant antiulcer activity against Indomethacin induced ulcers in rats and the antiulcer activity could be due to the presence of flavonoids as these compounds have well documented antiulcer activity.

Keywords: Citron, Gastric ulcer, Indomethacin, Flavonoids.