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Abstract

EVALUATION OF WOUND HEALING POTENTIAL OF CRUDE LEAVE EXTRACTS OF BIXA ORELLANA LINN. IN WISTAR RATS.

*Subhashree Padhi and Sangram K. Panda

ABSTRACT

The present study was an attempt to investigate the wound healing potential in two different types of wound models in albino rats viz., incision and excision. of various extracts of Bixa orellana leave. The different crude extracts such as ethanol, ethyl acetate, methanol and petroleum ether are obtained by successive soxhlet extraction. The ethanolic extract showed significant increase in wound contraction and formation of scar in excision wound model. The extract showed significant increase in the breaking strength of resutured incision wound as compared to control group(p<0.05). The result of the present study indicate that ethanolic extract of B. orellana has more significant wound healing property than the other three extracts in excision and incision wound model.

Keywords: Bixa orellana L.; Excision and incision wound model.


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