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  • AUGUST 2020 Issue has been successfully launched on 1 August 2020.

Abstract

EVALUATION OF GENOTOXICITY OF POTENTOX THROUGH AMES AND IN VITRO CHROMOSOMAL ABERRATION TESTS

Manu Chaudhary, Shailesh Kumar and Anurag Payasi*

ABSTRACT

The mutagenicity of Potentox was evaluated by two mutagenicity tests, the reverse mutation assay in bacteria and the chromosomal aberration test with Chinese hamster lung (CHL) cells. Strains of Salmonella typhimurium TA 98, TA100, TA1535 and TA1537 and Escherichia coli [WP2 (uvrA)] strain were used at the concentration ranging from 0.002 to 0.031 μg/plate in triplicates with and without S9 activation in the reverse mutation test. A Chinese hamster lung fibroblast cell line was used at dose levels 0.20, 0.40, 0.81, 1.62 and 3.25 mg/ml in the absence and presence of the metabolic activation in the chromosomal aberration test. Potentox produced no significant increase in the number of revertants in any of the strains at the dose levels where antibacterial effects were not noted with and without metabolic activation. Potentox did not increase in the incidence of cells with chromosomal aberration in the absence or presence of metabolic activation. These results suggested the Potentox has no mutagenic potential under clinical conditions.

Keywords: Potentox, reverse mutation test, S. typhi, E. coli.


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