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Abstract

FORMULATION AND EVALUATION OF RAPID DISINTEGRATING TABLETS OF ZOLMITRIPTAN-USING DIFFERENT SUPERDISINTEGRANTS

Y.Ganesh Kumar*, Ch.Anil kumar, D.Satyavati, B.Swetha, D.Narasimha Rao

ABSTRACT

Zolmitriptan is a Selective Serotonin receptor agonist of the 1B and 1D subtype. Used in the acute treatment of Migraine attacks with or without aura and headaches. The present research work is aimed at developing a Formulate and Evaluated of an Oro dispersible tablet dosage form of Zolmitriptan. The target of these new oral dissolving/disintegrating dosage forms have generally been pediatric, geriatric, bedridden and developmentally disabled patients and also patients with persistent nausea, who are in traveling, or who have little or no access to water are also good candidates for ODTs Direct Compression method was employed for blending of drug with polymers in the given ratio as a 9 formulations. The prepared powder blends were then compressed into tablets using the necessary Superdisintegrants (CCS, CP, and SSG) and Excipients. The tablets were evaluated for Weight variation, thickness, hardness, friability, Drug Content and Disintegrating Time (Sec) were subjected to a 10 minutes in vitro drug release studies (USP dissolution rate test apparatus II, 50 rpm, 370C 0.50C) using phosphate buffer, pH 6.8 as a dissolution medium (900ml). The amount of Zolmitriptan released from the tablet formulations at different time intervals was estimated using a UV spectroscopy method. The formulations that showed a considerable retardation of the drug release are considered promising. Among the nine formulations, F7 formulation containing Drug to Sodium Starch Glycollate (SSG) in ratio 1:1 is optimized based on its ability to till 7 mins of invitro dissolution time, and its % Cumulative Drug Release Of The 99% of dissolution study.

Keywords: Zolmitriptan, Sodium Starch Glycollate, Selective Serotonin receptor agonist, Migraine.


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