Abstract

A PRELIMINARY STUDY ON SIGNIFICANT ANTIHYPERGLYCEMIC ACTIVITY AS DETERMINED THROUGH ORAL GLUCOSE TOLERANCE TESTS OF THREE COMMON PLANTS BELONGING TO THE BRASSICACEAE FAMILY

Mahbuba Akther, Erena Islam, Md. Tabibul Islam, Protiva Rani Das, Md Ezazul Haque, Rownak Jahan, Abdullah Al-Nahain, Shahnaz Rahman, Mohammed Rahmatullah*

ABSTRACT

Background. Evaluation of antihyperglycemic properties through oral glucose tolerance tests in glucose loaded mice (Swiss albino) using three available plants from Brassicaceae family that are used as vegetables in Bangladesh as well as most parts of the world. Methods. Different doses of the extracts were orally administered to glucose loaded mice to investigate antihyperglycemic activity. Results. Methanolic extract of all the plants tested showed significant antihyperglycemic activity. The more interesting part of this work is that antihyperglycemic activity of these extracts was retained at a significant level even after they were boiled. Conclusion. Our investigation strongly suggests that both boiled and non-boiled form of these vegetables can be potential replacement of antidiabetic drugs for diabetic patients to control blood glucose level.

Keywords: Diabetes, antihyperglycemic, oral glucose tolerance test, Brassicaceae.