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Abstract

COLORIMETRIC METHODS FOR THE ESTIMATION OF TOPIRAMATE IN TABLETS

*P. G. Sunitha, R. Dhanalakshmi, A. Gangatharan, A. Kavi Bharathi, G. Murali Shankar and M. Sathya

ABSTRACT

Two simple sensitive and precise colorimetric methods A and B were developed for the estimation of topiramate in bulk drug as well as in pharmaceutical dosage form. Method A is based on the formation of purple coloured chromogen by diazotization and coupling reaction of topiramate with Bratton-Marshall reagent, which has absorption maximum at 551nm.Method B is based on the formation of an orange-red coloured complex with 1,10-Phenanthroline and ferric chloride which has absorption maximum at 508nm. The proposed methods are statistically validated and found to be useful for the routine determination of topiramate in tablets.

Keywords: Topiramate, Colorimetry, Tablets, Validation.


[Full Text Article]

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