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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

COLORIMETRIC METHODS FOR THE ESTIMATION OF TOPIRAMATE IN TABLETS

*P. G. Sunitha, R. Dhanalakshmi, A. Gangatharan, A. Kavi Bharathi, G. Murali Shankar and M. Sathya

ABSTRACT

Two simple sensitive and precise colorimetric methods A and B were developed for the estimation of topiramate in bulk drug as well as in pharmaceutical dosage form. Method A is based on the formation of purple coloured chromogen by diazotization and coupling reaction of topiramate with Bratton-Marshall reagent, which has absorption maximum at 551nm.Method B is based on the formation of an orange-red coloured complex with 1,10-Phenanthroline and ferric chloride which has absorption maximum at 508nm. The proposed methods are statistically validated and found to be useful for the routine determination of topiramate in tablets.

Keywords: Topiramate, Colorimetry, Tablets, Validation.

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