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Abstract

A VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANIOUS DETERMINATION OF AVIBACTAM AND CEFTAZIDIME IN BULK AND PHARMACEUTICAL DOSAGE FROM

Govind Suryawanshi*, Rajendra Bandal, Harole Mangesh and Pise Kalyan

ABSTRACT

The proposed study, a new stability-indicating method has been developed for estimation of avibactam and ceftazidime in bulk and pharmaceutical dosage form. The present method was a sensitive, precise and accurate RP-HPLC method for analysis of avibactam and ceftazidime. To optimize mobile phase, various combinations of buffer and organic solvent were used on Thermo ODS C18 (150mm x 4.6 mm, 5μ) column. Then mobile phase containing mixture of phosphate buffer and acetonitrile in ratio of 50:50 v/v was selected at flow rate 1.1 ml/min for developing method and peaks with good shape and resolution were found short retention time, baseline stability and minimum noise. The retention time of avibactam and ceftazidime was found to be 2.41 min and 3.54 min respectively. Quantitative linearity was obeyed in the range 12.5-75μg/ml and 50-300μg/ml of avibactam and ceftazidime respectively. The limit of detection and limit of quantitation were found to be 0.22ppm, and 0.68ppm (avibactam); 0.40ppm and 1.22ppm (ceftazidime) respectively, which indicates the sensitivity of the method. The high percentage of recovery indicates the proposed method is highly accurate. No interfering peaks were found in the chromatogram indicating that excipients used in injection formulation didn’t interfere with the estimation of the drugs by the proposed HPLC method.

Keywords: Chromatography, RP-HPLC, avibactam, ceftazidime.


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