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Abstract

MECHANISM OF ACTION OF TEMPOL IN ORGANOPHOSPHATE POISONING

Mauricio Alexandre Reis Junior* and Maisa Ribeiro Pereira Lima Brigagão

ABSTRACT

Malathion is an organophosphate of the most used in Brazilian agriculture. The lack of control and the indiscriminate use of organophosphate malathion cause various effects mutagenic, carcinogenic, neurotoxic and hepatotoxic associated with exacerbated production of reactive oxygen species. The objective of this study was to evaluate the nitroxide Tempol it is able to reduce the inflammatory process induced by organophosphate malathion. The concentration of tripeptide glutathione was determined by HPLC after derivatization of the samples with monobromobimane. To ensure standard methodology, the organophosphate malathion was quantified in plasma by gas chromatography and the concentration of O2- was quantified by continuously reducing Fe3+ to Fe2+ using ferricytochrome c at
wavelength 550 nm using a spectrophotometer. This project was evidenced an increase of O2- (using ferricytochrome C and a reduction of GSH / GSSG after induction of the inflammatory process by organophosphate (malathion). The administration of Tempol (anti-inflammatory prototype) increased the GSH / GSSG ratio and decreased production O2-, indicating a reduction of the inflammatory process induced by organophosphate poisoning. These results endorse the possibility of this nitroxide Tempol to be a promising prototype of a new class of anti-inflammatory for the treatment of population.

Keywords: Inflammation, Malathion, Tempol, Glutathione.


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