Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2021 Issue has been successfully launched on 1 March 2021.

Abstract

ANALYSIS OF INTERACTION OF HUMAN HEMOGLOBIN WITH QUERCETIN: FLUORESCENCE SPECTROSCOPIC AND MOLECULAR MODELING APPROACH

S. Bakkialakshmi* and Jayoti Roy

ABSTRACT

Quercetin (3,3',4',5,7-pentahydroxyflavone), a plant derived flavonoid posseses a wide range of therapeutic properties such as anti-oxidant, anti-cancer, anti-tumor, etc. The purpose of this communication is to examine the interaction of Quercetin with natural drug carrier, Human hemoglobin (Hb) utilizing absorption spectroscopy, steady-state fluorescence and synchronous fluorescence spectroscopy and molecular modeling. The results indicated that quercetin caused strong fluorescence quenching of Hb by static quenching mechanism. Stern-Volmer study indicates that static along with quenching mechanisms are accountable for the quenching of protein fluorescence by quercetin. Molecular docking studies support the interactions between Hb and quercetin as observed from spectroscopic studies.

Keywords: Human hemoglobin, quercetin, steady-state fluorescence, synchronous fluorescence, molecular docking study.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More