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  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2021 Issue has been successfully launched on 1 March 2021.

Abstract

DESIGN DEVELOPMENT AND EVALUATION OF MESALAMINE LOADED MICROSPONGE COMPRESSED INTO TABLET FOR COLON.

Swapnil Lembhe* and Asish Dev

ABSTRACT

Microsponge Drug Delivery System (MDS) is a patented technology has been successively used for the controlled release of topical agents which consist of macro porous beads, typically 10-25 microns in a diameter, which are loaded with active agent. Allowing a sustained flow of substances out of the sphere, the outer surface is typically porous, This system can suspend or entrap a wide variety of substances, and incorporated into a formulated product such as a liquid, gel, cream, or powder. The Microsponge shows time mode release when applied to the skin and they also response to other stimuli like rubbing, pH, etc. MDS technology is currently used in different dosage forms like cosmetics, over the counter (OTC) skin care, sunscreens and prescription products. Microsponge technology allows entrapment of ingredients and it also shows reduced side effects, more stability, increased elegance and enhanced formulation flexibility. In addition, various studies have showed that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microspheres can be prepared by different methods using emulsion system or by suspension polymerization in liquid system.

Keywords: Microsponge, Porous-beads, controlled-release, Quisi-emulsion-solvent-diffusion method, Liquid-liquid-suspension-method.


[Full Text Article]

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