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Abstract

FORMULATION AND EVALUATION OF ORAL FLOATING TABLETS OF AN ANTI DIABETIC DRUG

R. Sandeep*, Surinder Kaur, Falguni Das and Divya S. Kumar

ABSTRACT

In the present study, acarbose was used for preparing floating dosage forms that are designed to retain in the stomach for a long time an established drug delivery system for better eradication of pre-diabetic condition (such as obesity) in the treatment of diabetes. Hydroxy propyl methyl cellulose (HPMC K4 M) and Carbopol-934P of different ratios were used to formulate Hydro dynamically Balanced Systems (HBS) by direct compression technique. The prepared HBS tablets were evaluated in terms of their pre-compression parameters and post compression parameters like hardness, friability, weight variation, uniformity of drug content, percentage swelling study, in vitro floating studies, in vitro drug release and short term stability studies. The floating properties and drug release features were determined for the prepared HBS in 0.1 N HCl dissolution media. All the HBS formulations showed good in vitro floating properties with an optimum concentration of gas generating agents like sodium bicarbonate, tartaric acid and citric acid. The rate of drug release decreased with increased hardness of tablets. Optimum concentration of HPMC K4M (150mg) and Carbopol-934 (10mg) along with excipients was found to be beneficial in improving the drug release rate and floating properties. Among the five formulations(F1-F5), F5 was selected as the best formulation having lag time 38.33 seconds, percentage swelling 96% and percentage drug release 84.38% at the 6th hour with buoyancy time > 12 hours.

Keywords: Acarbose, Hydrodynamically Balanced Systems, Hydroxy Propyl Methyl Cellulose (HPMC K4 M), Carbopol-934.


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