Abstract

FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF FUROSEMIDE

Bhoopathi.G.S*, Jayanthi, Pramoda.G, Srikanth.S

ABSTRACT

The present study was to formulate and evaluate sustained release tablets of furosemide. The study is going to enhance the half-life and to reduce the diuresis peak while maintaining the quantity of drug excreted in urine within 24 h which equals to that drug excreted with fast release formulation. HPMC K4M, Xanthan gum, Chitosan and guar gum was used as matrix forming material, while Lactose is used as filler to maintain the tablet weight. The granules were analyzed to determine bulk density, tapped density, angle of repose and compressibility index. All batches of sustained release matrix tablets of furosemide were prepared by using different drug: polymer ratios by wet granulation method. The formulated tablets were analyzed for thickness, hardness, friability, weight variation, drug content and invitro drug release and kinetic data analysis was carried out. All the physical characters of fabricated tablets were within acceptable limits. Results showed that Formulation F3 shows good in-vitro drug release up to 12 hours (96.35%). The optimized formulation F3 was analyzed for kinetic data and the results indicating formulation F3 follows zero order kinetics. The n values obtained from korsmeyer-peppas plots ranges from (0.6230 to 0.8347) indicating that the mechanism of release of formulations (F-1 to F-12) was anomalous (non-Fickian) diffusion.

Keywords: Furosemide, Chitosan, Guar gum, Sustained release, Matrix tablets.