Abstract

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF WHOLE PLANT EXTRACT OF MANIKARA ZAPOTA LINN

Ayesha Khan*

ABSTRACT

The present study aims to explore the analgesics and anti-inflammatory activity of ethanolic extract of Manilkara zapota Linn. This was studied using Eddy’s hot plate method, acetic acid induced writhing andCarrageenin, histamine induced paw edema respectively. Treatment with both low dose 200mg/kg b.wt and high dose 400mg/kg b.wt of herbal ethanolic extract of dried powder of Manilkara zapota Linn increased the reaction time in the methods (eddy’s hot plate method, acetic acid induced writhing) confirming analgesic activity and similarly anti-inflammatory activity (Carrageenin and histamine induced paw edema) shown significant increases in percentage protection against paw volume. However, comparatively 400mg/kg b.wt dose of Manilkara zapota Linn is more efficacious. Further experimental studies need to be conducted to prove the effectiveness the active compound responsible for analgesic and anti-inflammatory activity.

Keywords: Manilkara zapota linn, Anti-inflammatory activity, Analgesic activity.