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K. Geetha*, S. Vineesha, N. Supraja, P. Meghana, G. Praveen Kumar


Ramipril is a prodrug and non sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de- esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II- induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. It has low bioavailability due to its first pass metabolism. In the present work, fast dissolving tablet of Ramipril was design with a view to and provide a quick onset of action. The main objective of the study was to formulate fast dissolving tablets of Ramipril to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving tablets prepared by direct compression and using super dis integrants in different concentration and evaluated for the pre-compression parameters. The prepared tablets were evaluated for post compressional evaluation. Among all the 9 formulations the best formulation is with 8 % of crospovidone (CP) showed faster disintegration time within 11sec when compared to the other formulations and it showed 98.6 % drug release at the end of 30 mins.

Keywords: Ramipril, direct compression, super dis integrants, in vitro disintegrating studies, in vitro dissolution studies.

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