Abstract

ISATIN ANTI-HIV AGENT: A REVIEW

Rahul Hajare*, Smita Kulkarni, Madhuri Thakar and Ramesh Paranjape

ABSTRACT

HIV-AIDS remains among the world’s great public health challenges. Worldwide resurgence of HIV is due to major problem outbreak of multi drug resistant HIV mutants can gain a competitive advantage over with respect to virus and become the dormant quasispecies Thus, there is persuasive need for anti-HIV drugs with improved properties such as, enhanced activity against MDR strains, reduced toxicity, shortened duration of therapy, low dose frequency, rapid mechanism of action and most important it will have been executing conformational adaptability and to increase flexibility to penetrate host cells and exert anti-retroviral effects in the intra and extra cellular environment. Indoline-2,3-dione (Isatin) derivatives are reported to show anti-HIV activities accordingly, isatin is a versatile lead molecule for designing of potential anti-HIV agent. The current review tracing isatin derivatives with potential anti-HIV activity.

Keywords: Isatin, Isatin analogues, Isatin binding proteins, Potential anti-HIV activity.