Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MARCH ISSUE PUBLISHED
  • MARCH 2021 Issue has been successfully launched on 1 March 2021.

Abstract

CURRENT TRENDS IN PHARMACOLOGICAL APPLICATIONS OF SARTANS

Dobrina D. Tsvetkova*, Danka P. Obreshkova, Stefka A. Ivanova, Vladimir P. Yankov, Peter Atanasov and Valentina B. Petkova

ABSTRACT

The aim of current study is to summarize the application of sartans for thetapy of hypertension and related cardiovascular diseases. Arterial hypertension is a widespread disease with more than 1 billion cases worldwide. Hypertension is one of the most significant social disease, leading to stroke, myocardial infarction and high mortality. A major advantage of sartans in comparison with ACE-inhibitors in the treatment of essential hypertension, is that not inhibit the degradation of bradykinin and other kinins and thus not cause the side effects (cough and angioedema) of ACE-inhibitors. Sartans are applied in a number of heart diseases: heart failure, atrial fibrillation, hypertension with left ventricular dysfunction, acute coronary syndrome, for protection of vascular endothelium and platelet aggregation, for prevention of stroke, cerebral ischemia, Alzheimer, Parkinson; and migraine. Blood pressure control is optimized by fixed-dose formulations of sartans with thiazide diuretic Hydrochlorothiazide (HCTZ): Candesartan (Atacand HCT), Irbesartan (Avapro HCT), Olmesartan medoxomil (Benicar HCTZ), Valsartan (Со-Valsacor).

Keywords: sartans, pharmacological application, clinical trials, combinations


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More